Ok, you say 28.3 knots, so thats 32.5 MPH at 5100 RPM's comes out to 30% prop slip, that's BAD! My 1st question is, has this prop always ran this way or is it only since being reworked? I've had more than a few props ruined after having been rebuilt by a prop shop. I'm close to one of the largest in Florida, and they've screwed up several of my props to the point they never ran right again, but looked perfect. The V-6 engines will ALWAYS have less cranking compression than the V-4's. Reason #1 is 88+ have idle reliefs to cut low RPM compression to make the engines run smoother. And reason #2 is the starter. V-4's have a direct drive starter whereas V-6's use a gear reduction, so V-4's spin over a good bit quicker.
As to you issue, an 18 pitch on a 200 JOHNNYRUDE is ALOT of prop for a 22 footer. I spun a 17 pitch on my 20 footer, but really should have had a 16 on it. I would be looking very HARD at your current prop in areas like cupping and rake for your lost performance. Alot of times prop shops don't have the correct block for a particuliar prop, so they use one thats close that they have on hand, and when they alter the blade design, it ruins the props performance. I had a little 3 blade stainless on a 25HP SUZUKI that looked like trash, but the engine spun up to around 5600, and the boat would hit 33 before it started chine walking so bad I let out of it. Had the prop rebuilt hoping it would help the chine walk, after rebuild the boat would only hit 26MPH(could run 29-30 with a cheap 4 blade aluminum), and barely spin up to 4500 RPM's. Experienced similiar results with several others, but put on brand new props and the performance came back.
In all honesty though, I would think a 22 footer with a 200 JOHNNYRUDE would do well with a 15-16 pitch in a fairly good biting prop. I have a STILLETO prop out in the shed that would probably run well for you, but you're a bit to far away to just let try it out, and shipping would probably be $40-50 through UPS.